Object

Alternative title:

Investigation of biological properties of electrospun PL-b-CL/PVP nanofibers modified with nanoparticles and antibacterial proteins – evaluation of cytotoxic effect as well as in vitro antibacterial and anticancer activities

Abstract:

Nanomedicine, currently one of the fastest developing fields of nanotechnology, offers new possibilities for effective methods of treating many diseases, including cancer or infections caused by highly antibiotic-resistant bacteria. It is a new therapeutic alternative to the often difficult diagnostics or not fully effective treatment methods. Nanomaterials are favored by their unique physicochemical and biological properties, mainly resulting from their small nanometric size. However, on the other hand, the wide spectrum of action and not fully understood toxicity mechanisms constitute a barrier to the medical use of nanomaterials, and therefore indicate the direction of many future studies. Therefore, electrospun polymer nanofibers, as innovative nanomaterials with great scientific and application potential, are currently the focus of many researchers from various fields, including tissue engineering, regenerative medicine, and controlled drug delivery systems. The main aim of this doctoral thesis was to develop new nanomaterials based on electrospun PL-b-CL/PVP nanofibers modified with nanoparticles and antibacterial proteins as well as assessment of their physicochemical and biological properties. The doctoral thesis consists of three original research papers published in the journals Nanomaterials, Macromolecular Bioscience and Nanotechnology, Science and Applications. All nanofibers were produced from a biocompatible and biodegradable copolymer PL-b-CL and PVP, and then modified with previously synthesized nanoparticles (CdSe QDs, AuNPs, Dend-AgNPs) and/or proteins (endolysin). The research used a wide range of physicochemical and biological methods, as well as various approaches and methods of nanofiber modification, which allowed for a comprehensive characterization of the developed nanomaterials and an assessment of their application potential.

Additional notes:

Zawiera bibliografię  ; Zawiera ilustracje Streszcz. ang.

Identifier:

oai:bibliotekacyfrowa.ujk.edu.pl:13692

Computer catalogue:

click here to follow the link

Language:

pol

Degree name:

doktor

Date obtained:

19.12.2025

Degree grantor:

Uniwersytet Jana Kochanowskiego w Kielcach

Supervisor:

Ciepluch, Karol

Reviewer:

Maciejczyk, Mateusz  ; Olczyk, Krystyna Kołodziejczyk-Czepas, Joanna

Field:

Dziedzina nauk ścisłych i przyrodniczych

Scientific disciplines:

Nauki biologiczne

Faculty:

Wydział Nauk Ścisłych i Przyrodniczych

Type:

rozprawa doktorska

Access rights:

tylko w Oddziale Informacji Naukowej

Publication status:

niepublikowana